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Digestive Enzymes, Probiotics, Vitamins, Minerals, Phytonutrients, Fatty Acids
Complementary Alternative Medicine (CAM).
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Water Soluble Vitamins
Fat Soluble Vitamins
Vitamins
Vitamin B-12 (Cobalamin)
General description
Vitamin B-12, also known as cobalamin, cyanocobalamin, and
hydroxycyanocobalamin, is a water-soluble vitamin in the B-complex vitamin
group. The B vitamins are used by the body as coenzymes. They are essential for
maintaining the skin, hair, liver, and good muscle tone in the gastrointestinal
tract. The B vitamins also help metabolize carbohydrates, proteins and fats.
Vitamin B-12 was discovered as a result of attempts to treat anemia. In 1926,
scientists discovered that eating liver once a day could reverse anemia. By the
late 1940s, cobalamin was isolated as the active ingredient in the liver that
effectively controlled the anemia.
Food sources
Cobalamin is found in foods such as beef, swiss and blue cheese, clams, eggs,
liver, and milk. It is not found in vegetables. Vegans, strict vegetarians who avoid
dairy products, are at high risk of becoming cobalamin deficient.
Health applications
Homocysteine
Mood
Cardiovascular health
Functions and uses
Cobalamin is involved in forming nucleoproteins and red blood cells, and in the
functioning of the nervous system. It is involved in cell activity, DNA replication,
and the production of the mood-affecting substance called SAMe
(S-adenosyl-L-methionine).
Dosage/toxicity
On average, dietary intakes of cobalamin are sufficient.4 In cases of elevated
homocysteine levels, doctors usually prescribe cobalamin supplementation
through injection, tablet, or capsule form. Cobalamin is also often available as a
constituent of multivitamin/mineral preparations. The RDA recommendation of
vitamin B-12 for adults is 2 mcg per day. The therapeutic range varies from
between 100 to 1,000 mcg. There is a very low incidence of vitamin B-12 toxicity,
even in intakes of up to 1,000 mcg per day.