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Digestive Enzymes, Probiotics, Vitamins, Minerals, Phytonutrients, Fatty Acids
Complementary Alternative Medicine (CAM).
                                           HEART DISEASE

What is heart disease?  Heart disease is an umbrella term for different diseases that affect the heart
and is the number one cause of death in the U.S., not the world the U.S. See, e.g.
Heart_disease .

Most, if not all of these diseases have one thing in common, lack of sufficient macro-nutrients. Remember the
proscription here, you must take
ALL of the recommended nutrients---digestive enzymes, probiotics, vitamins,  
minerals and phytonutrients--- to effectuate a significant change in your health. A key factor in the war against
heart disease is in the vitamin group, Vitamin C.

In 1968 Dr. Linus Pauling gave name and principle to the popular but controversial megavitamin therapy
movement of the 1970s. He coined the term "orthomolecular" to refer to the practice of varying the
concentration of vitamins and minerals normally required by the body to prevent and treat disease. His ideas
formed the basis of orthomolecular medicine, the theme of this website. Orthomolecular medicine is generally
not practiced by conventional medical professionals and amazingly strongly criticized by some, which we shall
see why  at the end of this article.
http://en.wikipedia.org/wiki/Linus_Pauling

Thirty-seven years ago, in 1970  Dr. Linus Pauling broke through to the public with his book, Vitamin C and
the Common Cold, and consumption of vitamin C rose by 300 percent and statistics show mortality from heart
disease decreased by 30%.

But, let’s digress a moment and look at this from a simple prospective. It is well known that most mammals
produce an abundance of vitamin C naturally and do not have heart disease. It is further well known that there
are four species of mammals that do not naturally produce their own vitamin C: 1. humans 2. gorillas 3. guinea
pigs and 4. fruit bats. All of these animals are vegetarian by nature, yes including humans. Humans are the
only species to both eat meat and be unable to produce vitamin C. There are no other carnivores which
cannot make Vitamin C.  The gorilla, guinea pig and lol, fruit bat are constantly foraging for vitamin C enriched
plant foods, vitamin C is produced by plants. They know instinctively what their bodies need to stay healthy.  

But man has evolved a temporary countermeasure to his inability to make vitamin c, when it is not available.
For instance, sailors were known to have had scurvy on long voyages, until someone discovered that a little
citrus fruit intake avoided the disease. Scurvy is marked by the breakdown of collagen tissue throughout the
body and frequent infections. Collagen is the protein with which strong connective tissue is made throughout
the body, including the cardiovascular system. The sailors died because scurvy was a disease marked by
leakage of blood out of  blood vessels. Their blood vessels literally cracked open (scurvy) and they bled to
death internally.

When a crack develops in a blood vessel wall due to a shortage of vitamin C, certain fat packages are formed
in the blood that have the ability to plug the leak by forming a kind of plaster cast. These packages of fat are
known as cholesterol, lipids, low density lipoproteins (LDL), and one especially effective leak plugger,
lipoprotein(a), a special type of LDL.

Now we have sufficient understanding where we can now answer the question. What is heart disease?  Heart
disease is started when once these fat packages have plugged the leak other passing  molecules of  
cholesterol (i.e. LDL) float by and glues or attaches itself to the pile. The process is as follows:

  • 1.   The vitamin C deficient crack in the blood vessel wall is the first step in atherosclerosis.

  • 2.   The plugging of the leak with lipoprotein(a) is the second step.

  • 3.   The gluing down of other LDL (single layer bags of cholesterol and lipids which are not sticky in        
themselves) is the third step.

  • 4.    The fourth step is the stimulation, by lipoprotein(a), of the muscle cells in the artery wall to  
multiply,  forming a tumor (swelling).

  • 5.    Then the cleanup crew arrives, also known as macrophages, and they try to eat the whole mess
    and  carry it away. However, many of them overeat, get fat, and become part of the problem by dying
    and  being glued down into the plaque. Because they contain so much fat, they appear under the
microscope to be full of foam, and they are therefore known as "foam cells."

The tumor, i.e., the proliferation of excess smooth muscle cells is not cancerous. Nevertheless, it can cause
death by pushing this mass of plaque into the lumen (passage way) of the blood vessel in which this process
is happening. This narrows the passage way through which blood passes and can eventually lead to heart
attack, stroke and other problems, depending on where in the body it develops.

Conversely, all the known actions of Vitamin C  against heart disease is that we know it:

  • 1.  Increases HDL (high density lipoprotein) production. (HDL is able to help resorb fat located in plaque.
In the process it changes from a disc shape to a globular form of HDL, and takes this fat to the liver to  
be burned.)

  • 2.  Decreases the production of lipoprotein(a). (Somehow the liver knows when there is plenty of
ascorbate on board, and therefore no need for high levels of lipoprotein(a) which is, after all, a repair  
factor for the cracks in blood vessel walls which come up in the absence of sufficient ascorbate.)

  • 3.   Down-regulates cholesterol and triglyceride production in the liver. [These are secondary repair
    factors
in that they are glued into the plaque by lipoprotein(a).]

  • 4.   Lowers blood sugar and insulin requirements.

  • 5.   By relaxing the blood vessel walls, lowers blood pressure when hypertension is present. (This is not
the total answer to a case of hypertension, but it can help.)

  • 6.   Inhibits inappropriate intravascular clot formation (the final and sometimes deadly event in cases of
heart attacks and strokes).

The bottom line is that lipoprotein(a) is the real risk factor in cardiovascular disease and that ascorbate and
niacin are the only major lines of defense against high levels of lipoprotein(a). Cholesterol, even LDL
cholesterol, can serve as a statistical risk factor only to the degree that it is correlated with the level of the real
problem: the special type of LDL called lipoprotein(a).

The best test, by far, for risk of cardiovascular disease is the direct measurement of this special type of LDL,
namely a lipoprotein(a) level. A lipoprotein(a) level is ten times more accurate and specific for prediction of
vascular disease. See the poor heart disease testing methods at the above wikipedia heart disease link.

If you want to protect yourself against the progression of heart disease, in conjunction with the 6
recommended nutrients, here is a plan for you in consultation with your physician:

  • 1.   Vitamin C to bowel tolerance — as much as you can take without diarrhea. For most people this will
    be  in the range of five to ten grams (5,000-10,000 mg.) each day. Spread this amount into two equal
    doses 12 hours apart. (Vitamin C prevents further cracking of the blood vessel wall — the beginning of
    the disease.)     

  • 2.   A 32 oz. bottle of water to refilled once afterwards and mixed with:
     a. 1/2 teaspoon of sea salt, to create a electrolyte solution
     b. 1/2 teaspoon of L-lysine (acts to release lipoprotein(a) from plaque formation
         and prevent further deposition of same). (cheaper purchased in bulk)
     c.
Optional 1/2 teaspon of L-proline (acts to release lipoprotein(a) from plaque
         formation and prevent further deposition of same). (cheaper purchased in bulk)
     d.
Optional 1/2 teaspoon of citric acid, if you are not eating your allotment of fruit
         (cheaper purchased in bulk 5 lbs about $10 bucks)
     e.
Optional 1 teaspoon of  xylitol if it must be sweetened

  • 3.   L-carnitine 3 grams twice each day (also strengthens the heart muscle).

  • 4.  Niacin decreases the production of lipoprotein(a) in the liver. Inositol hexaniacinate is a form of
    niacin which gives less of a problem with flushing and therefore allows for larger therapeutic doses.
    Begin with 250 mg. at lunch, 500 mg. at dinner and 500 mg. at bedtime the first day; then increase
    gradually over a few days until you reach four grams per day, or the highest dose under four grams you
    can tolerate. Be sure to aks your doctor for liver enzyme level tests every two months or less to be sure
    your liver is able to handle the dose you are taking.

  • 5.  Take digestive enzymes on an empty stomach and the enzyme serrapeptase

  • 7.  Vitamin E (as Unique E) 800-2400 IU per day. (This inhibits the proliferation of smooth muscle cells
    in the walls of arteries undergoing the atherosclerotic changes.)

  • 8.  Supplement with magnesium orotate (arguably the best form or magnesiuml

  • 9.   Adopt a sensible exercise program in collaboration with your doctor.

The preceding is based upon well-establish follow thru on patented authority. See  Linus Pauling Therapy for
Heart Disease at
http://www.paulingtherapy.com/ , which copiously describes a non toxic, cost effective
Orthomolecular approach using vitamin C and amino acids Lysine and Proline. Also see: NCCAM citing  
vitamin C as effective
NIH Citing Vitamin C as Effective. See also,  NCCAM Clinical Studies Conclusions
and Google Linus Pauling NIH Views

According to the Pauling/Rath 1994 United States patent # 5,278,189, the amino acid lysine (lysine analogs),
along with vitamin C and other antioxidants (e.g. Co-Q10, vitamin E and vitamin A), can, in sufficient
concentration, inhibit Lp(a) binding to exposed lysine residues. Proline residues are also exposed by lesions
in blood vessels. Later experiments showed that proline as well as lysine, with vitamin C, other amino acids
and antioxidants, in oral amounts well past what is needed for prevention, becomes a solvent by inhibiting the
binding of Lp(a). A binding inhibitor augmented with vitamin C can stop and apparently even reverses some
plaque formations.

Pauling and Rath even have a second U. S. patent for using these binding inhibitors as solvents to melt
atherosclerotic plaques from human organs during organ transplants. The organ is dipped in the Lp(a)
Binding Inhibitor solution and the plaques melt away.
Patent # 5230996

Dr. Pauling is one of about 8 renowned scientist whose paper's have been enshrined into the U.S.Department
of Health and Human Services National Institute of Health Archives (NIH). The National Library of Medicine is
collaborating with Oregon State University's Valley Library to digitize and make available over the Web this
selection of the Pauling Papers for use by educators, researchers, students, and the public. The University is
the repository for the Linus Pauling papers.

More ironic is that the NIH/NCCAM has established the Linus Pauling Institute at Oregon State University as
one of the two centers of excellence for micronutrient supplementation for optimal health.
http://lpi.oregonstate.
edu/resagenda/about.html

The NCCAM in conjunction with the National Heart, Lung and Blood Institute launched a 2002 study on the
synthetic amino acid ethylene diamine tetraacetic acid (EDTA) Chelation. This was the first-ever widescale
clinical trial to try and establish the effectiveness of chelation therapy in individuals with coronary artery
disease which remains the leading killer of both men and women in this country. The Food and Drug
Administration has approved EDTA, as a pharmaceutical agent for the treatment of lead and other heavy
metal poisoning or exposure. In older literature, the FDA also approved intravenous EDTA treatment as
"possibly effective in occlusive vascular disorders ... arrhythmias and atrioventricular induction defects ... and
in the treatment of pathologic conditions to which calcium tissue deposits or hypercalcemia may contribute
other than those listed above." These "possibly effective" indications were removed from FDA-approved
literature in the late 1970's for reasons known only to the FDA. The present study is to (sic) scientifically
confirm, once again that EDTA, simply stated removes clogged arteries of plaque.

One must exercise caution with this therapy as it removes vitamins and minerals from the body. Thus,  vitamin
and mineral intake must be increased, to maintain safe levels.
NCCAM NEWS RELEASE. Google EDTA
Chelation/Supplementation; Google EDTA Oral Supplementation


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